Preparation and Structural and Magnetic Characterizations of Hydroxyapatite/Zinc Ferrite Composite Nanoparticles for Future Cancer Treatment
Abstract
A promising composite of zinc ferrite (ZnFe2O4) and bioactive hydroxyapatite
(Ca10(PO4)6(OH)2 ;HAp) has expected to potential for future bone reinforcing formation. In
present study, zinc ferrite and hydroxyapatite composite was prepared by solid state
reaction route for easier control of structural and magnetic characteristics and with low
cost. Hydroxyapatite powder was synthesized by precipitation method from chicken
eggshell. Mixed powders with varying ZnFe2O4/HAp weight ratios from 2-10 wt% were
milled together and uniaxially pressed and then sintered at 1200 oC for 3 hours. The XRD
results showing no other phases of composite with only HAp and ZnFe2O4 phases were
identified, indicating high stability of HAp property. Phase fractions of ZnFe2O4 were found
to increase from 10.8 to 18.73 wt% with increasing content of ZnFe2O4. FT-IR results of
ZnFe2O4/HAp composite were only revealed vibration bands of standard HAp phase. This
may due to the overlapping of the ZnFe2O4 vibrational bands with HAp bands. However,
their intense variations observed in HAp vibrational bands indicated the interaction
between ZnFe2O4 and HAp. The surface morphology of these ZnFe2O4/HAp composite
exhibited primary grain in nano scale with enhanced pore structure and Interconnectivity
when ZnFe2O4 weight ratios increased; indicating high surface area for cell attachment
and better good cell growth and differentiation. The higher saturation magnetization as
well as higher super paramagnetic behavior could be easily altered by increasing ZnFe2O4
content in the composite.
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