Development of porous scaffold based on B-tricalcium phosphate, Zinc-Nikle ferrite, zirconia for bone tissue engineering application

Abstract

In this research, scaffolds of β-tricalcium phosphate (β-TCP) and zinc nickel ferrite (ZnxNi1-xFe2O4) were simply fabricated via the uniaxial pressing together with pressureless sintering, which can be tailored for specific applications. The morphology of ZnxNi1-xFe2O4/β-TCP scaffolds with all formulas obtained from the SEM result revealed the larger grains, the higher porosity and higher interconnectivity with increasing of ZnxNi1-xFe2O4 amount in β-TCP matrix. The high porous structure of the composite scaffold provided high surface area for cell attachment, indicative of good cell growth and differentiation. Biological in vitro test using direct contact method with human cells revealed that the composite scaffold of β-TCP and Zn0.8Ni0.2Fe2O4 with all ratios induced the higher growth of Human osteoblast cells and the better cell spreading on surface of specimens