Development of electrospun fiber mat based on silk sericin, thunbergia- laurifolia linn extract and horsetail extract for wound dressing application

Abstract

In this work, fiber mat based on silk sericin and thunbergia laurifolia linn extract was developed via electrospinning technique for wound dressing application. The waste cocoons were selected from Nakhon Ratchasima 1 (K1) with appropriate spicy for extracting the silk sericin protein. Trunk of thunbergia laurifolia linn was selected for preparing thunbergia laurifolia linn extract. Polyvinyl alcohol (PVA) with several concentrations were chose and fabricated to fibers by electrospinning technique to investigate suitable polymer concentration for mixing silk sericin and thunbergia laurifolia linn extract. The result revealed that PVA of 9 wt % was suitable due to Several parameters were investigated to prepare the electrospun fiber of silk sericin and thunbergia laurifolia linn extract such as their mixing ratio, voltage, the distance between the needle and the substrate and the needle size. The results indicated that mixing ratio of silk sericin and thunbergia laurifolia linn extract at 50:50 (w/w), voltage of 15 kV, the distance of the needle and the substrate at 8 cm and the needle size of 18 were optimum condition for the fabrication of electrospun fiber with diameter of 100-200 nm and that with smooth and continue feature.